A recent decision by a key CDC advisory panel is changing the conversation around early childhood vaccinations. If your child is under four, here’s what you need to know about the updated advice on the MMRV vaccine.

What’s New: A Shift to Separate Shots

In September 2025, the CDC’s Advisory Committee on Immunization Practices (ACIP) updated its guidance. The committee now recommends that children under four years old receive two separate shots: the MMR vaccine (for measles, mumps, and rubella) and the varicella vaccine (for chickenpox), instead of the combined MMRV vaccine.

This recommendation is based on data showing a small but increased risk of febrile seizures—seizures accompanied by a fever—in young children after receiving the combined MMRV shot, particularly for their first dose between 12 and 23 months. The separate shots carry a measurably lower risk.

Important Note: This change is about how the vaccines are given, not whether they are given. Vaccination itself remains critical for public health. The Vaccines for Children (VFC) program will continue to cover all recommended options.

Why This Matters for Your Family

The MMRV vaccine (often known by the brand name ProQuad) was popular for its convenience—one shot instead of two. However, safety is the top priority.

• Febrile Seizures: While frightening to witness, febrile seizures are typically short-lived and do not cause long-term harm. This policy shift is a precautionary measure to minimize this already rare risk.
• Logistics for Parents: The new guidance means more shots per visit or potentially an extra doctor’s appointment. Pediatricians are adjusting schedules to make this as smooth as possible for families.
• Maintaining Trust: With any change in vaccine policy, it’s normal to have questions. The best step is to have an open conversation with your pediatrician, who can provide advice based on the latest science and your child’s specific health needs.

What This Means for You: A Parent’s Checklist

1. Talk to Your Pediatrician: If your child is under four and due for these vaccines, discuss the best option—separate or combined—with their doctor.
2. Understand the Why: Remember, this change is a refined safety recommendation based on continuous monitoring, not an emergency.
3. Plan for Appointments: Be aware that your child may need two injections instead of one at their next visit. Your pediatrician’s office can help you plan the timing.
4. Check Coverage: While coverage remains in place, it’s always a good idea to confirm with your insurance provider.

Answers to Common Questions

• “Is the MMRV vaccine unsafe?” No. The vaccine remains a safe and effective tool. This is a nuanced update to further reduce a very small risk for a specific age group.
• “Will this make it harder to get my child vaccinated?” The goal is to maintain easy access. While it may mean an extra shot, your doctor’s office will work with you to ensure your child gets the full protection they need.
• “What should I do next?” The most important thing is to keep your child on a vaccination schedule. Your pediatrician is your best resource for navigating this update.

Looking Ahead

Health officials will be watching how this change affects vaccination rates and public health. The key takeaway is that vaccine safety systems are working—they are constantly reviewing data and making adjustments to ensure the well-being of our children.